摘要
通过用蝮蛇抗栓酶（Ｓｖａｔｅ）对家兔实验性动脉粥样硬化（ＡＳ）影响的观察，发现Ｓｖａｔｅ能明显抑制家兔主动脉ＡＳ，同时能明显降低血液丙二醛、血栓素及甘油三酯含量，能升高血液超氧化物歧化酶活性及前列环素含量。说明Ｓｖａｔｅ能预防ＡＳ，其机制与Ｓｖａｔｅ减轻自由基损伤、恢复前列环素／血栓素平衡及降血脂密切相关。
Our experimental observations of the effcet of snake Venom antithrombotic Enzyme(Svate)on rabbit atherosclerosis(AS),show that svate can inhiht AS of the rabbit aorta effectively. It can also significantly reduce the blood level of malondialdehyde(MDA),thromboxane(TXA_2)and Triglyceride(TG),enhance the activity of superoxide dismutase(SD) and increase the blood confert of prostacyclin(PGI_2).Our results indicate that svate can prevent AS,and the mechanism is related to the fact that svate can minimige the injury produced by oxygen free radical.maintain the balance of PGI_2/TXA_3 , and lower the level of Triglyceride (TG).
出处
《蛇志》
1995年第2期14-17,共4页
Journal of Snake
