摘要
本文研究了乌桕、射干和巴豆油分别对3—甲基胆蒽(3—metycholanthrene)诱发小白鼠背部皮肤肿瘤的促进作用。实验结果表明,用药后42周,乌桕、射干和巴豆油组小白鼠背部皮肤的肿瘤发生率分别是30％,27％和70％,而对照3—甲基胆蒽组的小白鼠没有发生皮肤肿瘤。因此,我们认为:乌桕和射干为促肿瘤发生物质,它们的促肿瘤发生作用弱于巴豆油。
In this experiment, mice skin papilloma induced by 3-methycholanthrene(3-MC) was promoted by sapjum sebiferum, Belamcanda chinensis and the typical promotor-Croton oil, respectively. The mice were divided into sixgroups. They were treated by 1) 3 MC plus Sapium sebiferum . 2) 3-MC plus Belamcanda chimensis. 3} 3-MC plus Croton oil. 4) 3-MC- 5) Sapium sebiferum and 6 ) Belamcanda chinensis alone. Firstly 0.2ml of 3-MC(400*g/ml ) in acetone was smerared on the back of mice in group l-4and 0.2ml of acetone was smeared on the back of mice in group 5 and 6. Two weeks later, the ethereal extracts of the drugs mentioned abouve were smeared on mice's back twice a week, for 45 weeks, res pectively. After s17 weeks, the first papilloma appeared.The results showed that, the incidences of papilloma in the mice of the first three groups were 30%, 27%, and 70% respectively. After 45 weeks no papilloma occurred in mice of the three cotrol groups 4,5,6 i.e. 3-MC, Sapium sebiferum and Belamcanda chinensis used alone). The conclusion is that Sapium sebiferum and Belamcanda chinensis are also tumor promotors, but with weaker promoting effect as compared to Croton oil.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1989年第5期350-352,共3页
Chinese Journal of Cancer
