摘要
将体外培养的海南株恶性疟原虫感染宿主红细胞后,发现感染红细胞抗氧化体系中的超氧化物岐化酶和过氧化氢酶的活性明显降低,还原型谷胱甘肽的含量明显下降,过氧化氢显著增加,表明疟原虫感染可使宿主红细胞内抗氧化体系的抗氧化能力下降。
In order to probe into the redox state in erythrocytes infected with P. falciparum, parasites of Hainan strain (FCC-1/HN) were cultured in vltro and trophozoites and schizonts were obtained by Percoll gradient separation. The effects of P. falciparum infection on antioxidative system and active oxygen level in erythrocytes were studied. It was found that the activities of superoxide dismutase, catalase and the content of reduced glutathione in infected erythrocytes were markedly decreaced, while the activities of glutathione peroxidase and glutathione reductase in infected erythrocytes remained unchanged. There was no evident increase in superoxide in infected erythrocytes. How-ever, the Lvel of hydro en peroxide in infected erythrocytes was markedly increased.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
1989年第3期194-196,共3页
Chinese Journal of Parasitology and Parasitic Diseases
基金
自然科学基金
