摘要
２０例体外循环心内手术患者被随机分为对照组和实验组，各１０例。实验组干预充液中加入抑肽酶２ｘ１０６血管舒张素抑制单位（ＫＩＵ）。结果发现，体外循环期间，对照组的血栓素Ｂ２（ＴＸＢ２）及其与６－酮－前列腺素Ｆ１ａ比值（ＴＸＢ２／６－Ｋ－ＰＧＦ１ａ）明显升高；实验组ＴＸＢ２的增加及ＴＸＢ２／６－Ｋ－ＰＧＦ１ａ的值明显低于对照组；实验组的血小板聚集率下降程度明显低于对照组，术后纵隔引流量减少４１．７％。表明抑肽酶可于体外循环期间抑制ＴＸＢ２的合成和释放，降低ＴＸＢ２／６－Ｋ－ＰＧＦ１ａ的值，从而保护血小板功能。
wenty patients undergoing cardiopulmonary bypass (CPB) for cardiac operations were di-vided into the control group and the aprotinin group at random. Patients of the aprotinin group re-ceived aprotinin 2 × 106 KIU in the priming volume of the CPB. Results showed that the level ofTXB2 and TXB2/-6-K-PGF1α ratio rose obviously during CPB in the control group; the increasedvolurne of TXB2 and TXB2/6-K-PGF1α ratio in the aprotinin group was lower than that in the con-trol group; level of paltelet aggregability in the aprotinin group was significantly lower than thatin the control group. At first 24 hours postoperative blood loss was reduced by 41. 7% in theaprotinin group as compared with that in the control group. These findings indicate that aprotininadministration during CPB can inhibit the synthesis and release of TXB, and decrease TXB2/6-K-PGF1α ratio,and protect platelet function.
出处
《南京铁道医学院学报》
1995年第2期97-98,105,共3页
Journal of Nanjing Railway Medical College
