摘要
报告了小剂量环孢素Ａ（ＣｙＡ）治疗严重银屑病的临床和血清细胞因子研究情况。６例严重的银屑病患者经ＣｙＡ治疗４～８周后临床症状基本消失。血清细胞因子研究结果如下：（１）银屑病患者血清ｓＩＬ－２Ｒ、ＩＬ－２及ＴＮＦ－α水平明显升高；（２）ＣｙＡ治疗银屑病症状缓解后血清ｓＩＬ－２Ｒ、ＩＬ－２水平明显降低，其中ＩＬ－２降至正常水平，ｓＩＬ－２Ｒ明显降至正常水平以下，血清ＴＮＦ－α仍明显高于正常水平。分析表明，ｓＩＬ－２Ｒ、ＩＬ－２及ＴＮＦ－α很可能参与了银屑病的发生与发展，ＣｙＡ治疗银屑病很可能是通过阻止ＴＨ细胞活化，抑制ＩＬ－２生成及ＩＬ－２Ｒ表达发挥治疗作用。
The effectiveness of low doses of cyclosporine A treatment in 6 patients with severe psoriasis was studied.the lesions cleared within 4 to 8weeks after starting treatment.The study of serum cytokines showed that the levels of SIL-2R.IL-2 and TNF-α were significantly elevated in active psoriatic patients compared with normal controls. After 4 to 8 weeks of cyclosporine treatment,all patients went into remission and the levels of SIL-2R.IL-2 were significanfly reduced, with IL-2 deceaced to normal levels and SIL-2R to levels significantly lower than normal.Our results suggerted that IL-2.SIL-2R and TNF-α are probably related with the pathosenesis and development of psoriasis,and cyclorporine's effect in psoriasis is probably mediated by inhibiting TH cell activation and blocking IL-2 production as well as IL-2R espression.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
1995年第2期78-80,共3页
Journal of Clinical Dermatology
