摘要
目的:比较皮下连续输注速效胰岛素类似物Aspart与常规静脉小剂量胰岛素输注疗法治疗糖尿病酮症酸中毒的疗效。方法:34例糖尿病酮症酸中毒患者随机分为2组。胰岛素泵联合Aspart组(n=17)及常规静脉胰岛素输注组(n=17)。观察患者住院时间,控制血糖所需时间(h)和所需胰岛素的量;纠正酮症酸中毒所需要的时间(h)和所需要的胰岛素量以及不良反应低血糖发生情况等。结果:Aspart皮下注射组和胰岛素静脉注射组在控制血糖<13.8mmol/L所需时间(h);血糖控制<13.8mmol/L所需胰岛素的量;纠正酮症酸中毒所用胰岛素量以及患者住院时间方面均无明显统计学差异(P>0.05)。而纠正酮症酸中毒所需要的时间在Aspart组为15.4±1.4h,静脉注射组为18.5±2.5h,Aspart组明显低于常规静脉注射组,具有统计学意义(P=0.0002)。结论:采用皮下连续输注速效胰岛素类似物Aspart治疗糖尿病酮症酸中毒是安全有效的,可能对患者及早改善代谢紊乱状态有一定帮助。
Obiective：To compare the efficacy and safety of continuous subcutaneous insulin As- part infusion therapy （CSIAI） with a traditional low-dose intravenous （IV） infusion therapy of reg ular insulin in patients with diabetic ketoacidosis （DKA）. Methods： A total of 34 consecutive patients admitted with DKA were randomly divided into two groups. CSIAI （n = 17） and IV group （n = 17）. Observation parameters were days of hospitalization, the duration of treatment until correction of hyperglycemia and ketoacidosis, amount of insulin administration until correction of hyperglycemia and ketoacidosis and the number of hypoglycemic events among treatment groups. Results：There were no statistical differences in the mean duration and insulin amount of treatment until correction of hyperglycemia, mean insulin amount of treatment until correction of DKA and the length of hospital stay,respectively（P〉0. 05）. There was significant difference for the mean duration of treatment until correction of DKA between CSIAI group（15.4 ± 1. 4 h）and IV group （18. 5 ± 2. 5 h, P = 0. 0002）. The duration of treatment until correction of DKA was shorter when patients were treated with insulin Aspart by insulin pump. Conclusions： Our results indicate that the use of continuous subcutaneous insulin aspart is safe and effective. It may be helpful for correction of metabolic abnormality of DKA in shorter time.
出处
《内科急危重症杂志》
2005年第4期161-163,共3页
Journal of Critical Care In Internal Medicine
