摘要
目的了解Child B／C级肝硬化脾功能亢进病人切脾断流术后纤维化指标的变化。方法对15例Child B／C级肝硬化脾功能亢进病人行切脾＋断流术，对比术前1-2wk和术后4wk内的透明质酸（HA）、甘胆酸（CG）、Ⅲ型前胶原（PCⅢ）、层粘连蛋白（LN）、Ⅳ型胶原（ⅣC）的变化。结果15例病人的HA、CG、PCⅢ、LN、ⅣC等纤维化指标均有一定程度下降，其中CG、LN、ⅣC有显著下降（P〈0．05）。结论肝硬化脾功能亢进病人切脾断流术可使纤维化指标改善。
Objective To understand the changes of fibrotic indexes after splenectomy with high perigastric and low esophagus venous ligation in Child B/C patients with hypersplenism secondary to cirrhosis. Methods Splenectomy with high perigastric and low esophagus venous ligation were performed in 15 patients with hypersplenism secondary to cirrhosis. Serum hyaluronic acid （HA）, cholyglycine （CG）, type-Ⅲ-procollagen （PCⅢ）, laminin （LN）, type-Ⅳ-collagen （ⅣC） levels were compared between 1-2 week before and 4 weeks after surgery. Results Serum HA, CG, PCⅢ, LN, and IVC decreased after surgery in all 15 patients; among them, CG, LN, and ⅣC decreased significantly （P〈0.05）. Conclusion Splenectomy with high perigastric and low esophagus venous ligation could improve fibrotic indexes in patients with hypersplenism secondary to cirrhosis.
出处
《世界感染杂志》
2005年第4期324-325,338,共3页
World Journal of Infection
