7Sangro B, Mazzolini G, Ruiz J,et al. Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors [J]. J Clin Oncol,2004 ;22 (8):1389.
8Kang WK, Park C, Yoon HL,et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study [J]. Hum Gene Ther, 2001; 12(6): 671.
3Stern AS, Podlaski FJ, Hulmes JD, et al. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells[J]. Pro Natl Acad Sci USA, 1990,87( 17 ) :6808-6812.
4Lamont A, Adorini L. IL-12:A key cytokine in immume regulation [ J ]. Immunol Today, 1996,17 ( 5 ) :214-217.
5Wolf SF, Temple PA, Kobayashi M, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effect of T and natural killer cells[J]. J Immunol, 1991,146(9) :3074-3081.
6Chan SH, Perussia B, Gupta JW, et al. Induction of interferon gama production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other induers[J]. J Exp Med,1991,173(4) :869-879.
7Sieburth D, Jabs EW, Warrington JA, et al. Assignment of genes encoding a unique cytokine ( IL12 ) composed of two unrelated subunits to chromosomes 3 and 5[J]. Genomics, 1992,14( 1 ) :59-62.
8Schoenhaut DS, Chua AO, Wolitzky AG, et al. Cloning and expression of murine hIL-12 [ J ]. J Immunol, 1992,148 ( 11 ) :3433-3440.
9Yoshimoto T, Wang CR, Yoneto T, et al. Reduced T helper 1 responses in hIL-12 P40 transgenic mice[J]. J Immunol, 1998,160(2) :588-594.
10Cheng S, Feckler C, Barnes WM, et al. Effective amplification of long targets from cloned inserts and human genomic DNA[J]. Proc Nail Acad Sci USA, 1994,91(12) : 5695-5699.
