摘要
目前肿瘤基因治疗尚存在许多问题,距临床应用还有相当的距离,但是在传统的放疗、化疗和手术治疗的基础上,辐射与基因治疗的有机结合在肿瘤治疗中却显示出可喜的前景。综述了近年来这一领域的研究进展,探讨了这一疗法对肿瘤治疗的应用前景。
Although tumor gene therapy has a distance to clinical use due to some problems, the combination of irradiation and gene therapy holds much promise in cancer therapy based on the traditional radiotherapy, chemotherapy and surgery. We have termed this therapeutic radiogenic therapy. This review focuses on the group of radiogenic therapy that are either: ⑴ improvement of gene transfer efficiency by irradiation; ⑵ radiotherapy combined with cytokines gene delivery or enhancement of the immunity of tumor cells by transgene; ⑶ directly stimulated by radiation to produce either directly or indirectly cytotoxic (agents;) ⑷ increasing of radiosensitivity in gene therapy; ⑸ radioprotective gene therapy-enhances radiation tumor killing effect while protecting the normal tissue and organs with transgene using transfer vector.
出处
《原子核物理评论》
CAS
CSCD
北大核心
2005年第2期219-224,共6页
Nuclear Physics Review
基金
中国科学院2002年度百人计划基金资助项目
科技部重大基础研究前期专项基金资助项目(2003CCB00200)~~
关键词
辐射
基因治疗
肿瘤
radiation
gene therapy
tumor
