摘要
目的探讨活化血小板CD62P、CD63在2型糖尿病患者中表达及临床意义。方法采用流式细胞仪测定76例2型糖尿病患者(包括有微血管病变者42例,无微血管病变者34例)及34例健康体检者(对照组)活化血小板标志物CD62P、CD63的表达。结果2型糖尿病患者CD62P、CD63表达与对照组比较有极显著性差异(P<0.01),有微血管病变组与无微血管病变组比较有极显著性差异(P<0.01)。结论2型糖尿病患者活化血小板表达明显增高,微血管病变的发生与活化血小板的高表达有密切关联。
Objective To study the expression and clinical value of CD62P and CD63 in patients with type 2 diabetes mellitus. Methods Using FCM and specific monochonal antibodies against activatied platelet . We detected the expression of CD62P and CD63 on platelets from 76 cases with type 2 diabetes mellitus （42cases wing microangiapathy ,34 cases without microangiopathy ）and 34 healthy controls. Results The levels of CD62P and CD63 on platelets of the patients with type 2 DM were significantly higher than in controls（P〈0.01）, the levels of CD2P and CD63 in type 2 diabetes niellitus with microangiopathy increased singificantly in corparison with types 2 diabetes Melliatus without microangiopathy（P〈0. 01）. Conclusion The results indicate that the expression of CD62P and CD63 were more activetred in patients with the type 2 diabetes mellitus and it may play an important role in the progression of type 2 deatetas mellitus microangiopathy.
出处
《华中医学杂志》
2005年第4期233-234,共2页
Central China Medical Journal
