摘要
目的:比较顺铂分别以低渗、等渗溶液行腹腔化疗时,二者药代动力学的差别,为临床上应用顺铂行腹腔低渗性化疗,提供理论依据。方法:采用12只杂交犬为研究对象,随机分为实验组(n=6)、对照组(n=6)。实验组为顺铂低渗腹腔化疗组,对照组为顺铂等渗腹腔化疗组。两组动物分别行腹腔化疗后,在15min、30min、1h、3h和6h采取外周血、门脉血和腹腔液。采用非火焰原子吸收光谱法检测外周血、门脉血和腹腔液中铂的含量。结果:实验组与对照组相比,前者腹腔液中铂的含量明显低于后者;而外周血、门脉血中铂的含量二者无明显差别。结论:顺铂腹腔低渗化疗时,可使腹腔液中的铂向腹膜组织中扩散量增加。
Objective： To compare the difference of pharmacokinetics between the intraperitoneal chemotherapy with cisplatin in hypotonic solution and in isotonic solution and to provide a theoretical evidence for clinical use of intraperitoneal cisplatin therapy in hypotoinic solution. Methods： Twelve hybrid dogs were used as the experimental objective. Experimental groups were intraperitoneally administrated with cisplatin in hypotonic solution （cisplatin was prepared with distilled water）, and the patients in control group received intraperitoneal chemotherapy with cisplatin in isotonic solution. （cisplatin was prepared with isotonic saline）. After two groups all received intraperitoneal chemotherapy, the peripheral blood, portal blood and peritoneal fluid were collected in 15 minute, 30 minute, 1 hour, 3 hour and 6 hour, respectively. The platinum amount of peripheral blood, portal blood, peritoneal fluid was quantitated by flameless atomic absorption spectrophotometry. Results： There was a significant decrease of the platinum amount in peritoneal fluid of the experimental group, as compared with control group. There was no significant difference between the platinum amount in peripheral blood, the portal blood in experimental group and the control group. Conclusion： Administration of intraperitoneal chemotherapy with cisplatin in a hypotonic solution results in the diffusion amount of platinum in peritoneum to increase.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2005年第15期844-846,共3页
Chinese Journal of Clinical Oncology
基金
卫生部临床学科重点项目基金资助(编号:97100250)
关键词
腹腔转移
低渗
顺铂
腹腔化疗
Peritoneal metastasis Hypotonic Cisplatin Intraperitoneal chemotherapy
