摘要
目的:为了提高晚期恶性肿瘤的治疗效果,分析特尔立联合顺铂对恶性腹腔积液的疗效及毒副反应。方法:在综合治疗的基础上,将58例患者随机分为两组:生物化疗组(在抽腹腔积液后腔内依次注入特尔立150～225μg+生理盐水5ml及顺铂20～40mg+生理盐水50ml)及单纯化疗组(在抽腹腔积液后腔内注入等量顺铂)。结果:生物化疗组完全缓解(CR)63.89%,部分缓解(PR)25.00%,无效(NC)11.11%,总有效率88.89%;单纯化疗组,完全缓解(CR)13.64%,部分缓解(PR)27.27%,无效(NC)59.09%,总有效率40.91%。生物化疗组总有效率明显高于单纯化疗组(P<0.05)。两组患者均未出现严重的毒副反应,生物化疗组发热反应明显多于单纯化疗组。结论:特尔立联合顺铂治疗恶性腹腔积液较单用顺铂有效率高。
Objective： In order to improve the quality of life of the advanced cancer patients, the efticaey toxic and side effects combined treatment of rHuGM - CSF with cisplatin for malignant celiac effusion. Methods： On the basis of comprehensive therapy, we randondy divided 58 patients into two groups： the bioehemotherapy group （after extracting the celiac effusion intraabdominal injection of rHuGM - CSF 150 - 225μg ＋ NS 5ml and eisplatin 20 - 40 tog ＋ NS 50 ml ） and simple chemotherapy （ after extracting celiac effusion intra-abdominal injection of cisplatin alone）. Results： The CR rate, PR rate, NC rate and CR ＋ PR rate of biochemotherapy group were 63.89%, 25.00%, 11.11%, 88.89% respectively, and 13.64%, 27.27%, 59.09%,40.91% in simple chemotherapy group, respectively. The RR was significantly higher than that of simple chemotherapy group （P 〈 0.05）. In the two groups there were no serious toxic or side effects, but the proportion of patients with fever in biochemotherapy group was significantly higher than that of the simple chemotherapy group. Conclusion： rHuGM - CSF combined with cisplatin could have better efficacy than cisplatin alone in the treatment of malignant celiac effusion.
出处
《华西医学》
CAS
2005年第3期436-438,共3页
West China Medical Journal
关键词
特尔立
顺铂
恶性腹腔积液
生物化疗
rHuGM- CSF
Cisplatin
Malignant celiac effusion
Biochemotherapy
