摘要
目的通过流行病学调查,探讨与类风湿关节炎(RA)发生有关的危险因素,估计各主要危险因素的相对危险度。方法应用1:1匹配的病例—对照研究方法,收集RA患者及对照各165例,收集的资料包括人口学特征、既往疾病史、家族史、吸烟、饮酒、饮茶等生活习惯和嗜好、居住和工作环境,以及女性月经史、生育史。对各危险因素进行单因素和多因素条件Logistic回归分析。结果与RA危险性增加有关的因素有阳性家族史、未受过高等教育、既往结核病史、中度及中度以上劳动强度和既往腮腺炎病史(OR=2.10￣5.41),女性第一次生育后哺乳史(OR=2.25)及初潮年龄晚(OR=2.17)与RA危险性的增加也有关,饮绿茶(OR=0.27)可降低RA发病的危险性。结论阳性家族史、未受过高等教育、既往结核病史、中度及中度以上劳动强度、既往腮腺炎病史和女性第一次生育后哺乳史、初潮年龄晚是RA发生的危险因素,饮绿茶对RA的发生具有保护作用。
Objective To investigate the risk factors associated with RA and to estimate the odds ratios of risk factors. Methods Using 1 ： 1 matched case-control study, 165 cases and 165 controls were included.Odds ratios （OR） of risk factors were calculated by univariate and multivariate conditional logistic regression models. Results Family history, low education level, moderate or heavy physical stress, tuberculosis, mumps were associated with increased risk of RA. For female patients, the age of first breasffeeding and delayed menarche were also risk factors. Green tea drinking was associated with decreased risk of RA. Conclusion Family history, low education level, tuberculosis, moderate or heavy physical stress, mumps, age of first breastfeeding, delayed menarched are risk factors associated with RA, while drinking green tea maybe a protective factor.
出处
《中华风湿病学杂志》
CAS
CSCD
2005年第8期482-484,共3页
Chinese Journal of Rheumatology
