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急性心肌梗死患者血管内皮生长因子动态变化的临床研究 被引量：1

Clinical study on series changes of vascular endothelia growth in patients with acute myocardial infarction
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摘要 目的探讨血管内皮因子(VEGF)在急性心肌梗死(AMI)中的动态变化及其与梗死灶大小的关系。方法采用双抗体ELISA法测定46例AMI患者的第1、7和28天血清VEGF水平,并分析其与梗死程度的关系。结果AMI发生后血清VEGF即开始升高,在第7天时达到高峰,第28天仍维持较高水平。AMI血清VEGF水平与梗死程度正相关。结论血清VEGF在AMI发生后呈动态变化,血清VEGF与AMI的梗死程度有关,提示动态检测血清VEGF对判断AMI的预后可能有一定指导意义。 [Objective] To investigate the series changs of. serum vascular endothelial growth factor （VEGF） and their clinical significance in patients with acute myocardial infarction （AMI）. [Methods] Serum levels of VEGF were measured by standarel quantitive sandwich ELISA at day 1, 7 and 28 after the onset of AMI in 46 patients. [Resuits] Serum VEGF showed a dramatic increase in serum of AMI patients soon after onset of stroke. Mean concerntration of VEGF peaked after 7 days and was maintained up to 28 days, and was correlated with the size of infarct.[Conclusion] Serum VEGF demonstrated a series changes after AMI onset, and was associated with the size of infarct, which suggest that serum VEGF could be a marker indicating clinical eharateristies of AMI.
作者 张国刚 杨天仑
机构地区 中南大学湘雅医院心内科
出处 《中国现代医学杂志》 CAS CSCD 北大核心 2005年第14期2190-2191,2193,共3页 China Journal of Modern Medicine
关键词 血管内皮生长因子 心肌梗死 vascular endothelial growth factor myocardia infarction
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献9

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共引文献14

同被引文献9

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中国现代医学杂志
2005年 第14期

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