摘要
选用５０只４周龄雌性ＳＤ大鼠，随机等量地分为实验组和对照组，实验组大鼠配戴自制上颌斜面导板式功能矫治器引导下颌前伸，应用荧光组织化学法对大鼠髁突软骨中雌激素受体（ＥＲ）进行定位及半定量分析。结果表明，大鼠髁突软骨中存在ＥＲ，且主要位于胞浆中；ＥＲ在软骨的生发层细胞中分布最多，且髁突软骨增生旺盛时分布较多；功能矫形前伸下颌后，髁突软骨各层细胞中ＥＲ的分布均较对照组明显增加，以生发层细胞的增加最明显。表明ＥＲ与髁突软骨的增生、分化及适应性生长改建关系密切。
Abstract Fifty female SD rats of 4-week-old were selected.divided equally and randomly into experimental and control groups.Simulated functional appliances were used to guide the mandibles of the rats forward.The animals were sacrificed after 3 days,1 week,2 weeks,3 and 4 weeks,The method of direct fluorescent histochemistry was performed to locationally and semi-quantitively detect estrogen receptor(ER) in the condylar cartilages,The results showed:①ER distributed in the various layers of the condylar cartilages of the rats,mainly in the germinal and transitional layers. ②ER located mainly in the cytoplasm of the chondrocytes. ③The.distribution of ER was increased statistically after functional mandibular protrusion,especially during the peried of the active proliferation of the condylar carti-Lges.It is suggested that ER had a close relationship with the hyperplasia and hypertrophy of the condylar chondrocytes and it played an important role in the (process of) proliferation and functional adaptive remedelling of the condylar cartilages after functional mandibular protrusion.
出处
《华西口腔医学杂志》
CSCD
北大核心
1995年第4期227-230,共4页
West China Journal of Stomatology
基金
国家自然科学基金
