摘要
因胸痛接受选择性冠状动脉造影７８例，其中有冠状动脉病变者５ｌ例，冠脉造影正常者２７例。测定所有病例的胆固醇、甘油三脂、高密度脂蛋白及其亚组分、载脂蛋白Ａ１和Ｂ１００分析冠脉病变程度与血清脂类和载脂蛋白的相关性，比较后二者对冠心病的辨别力，结果表明：单项指标对冠心病的辨别力以载脂蛋白Ａ１为佳；血脂分组比值以非高密度脂蛋白与高密度脂蛋白之比为优。提示测定载脂蛋白Ａ１和Ｂ１００以及非高密度脂蛋白与高密度脂蛋白之比对于临床预测冠脉病变有实用价值。
he levels of serum lipid and
apolipoproteins(Apo) were measured in 78 cases under-going coronary artery angiography
because of chest pain,Fifty-one subjects suffered fromcoronary artery disease(CADand 27
appeared normal;Major coronary arteries(CA)withsignifcantly occlusive disease were examined
using the scoring method to reflect lesion ex-tent and narrowness of CA. The two groups were
compared in lipid and Apo levels. The re-sults showed that levels of ApoA1,HDL-C and HDI2-C
were significantly lower and TC,TG,ApoB100 were higher in CAD Group than those in the control
groups. Discriminativeanalysis indicated that ApoA1 was the best discriminator and NHDL/HDL
value was thenext.MuItiple stepwise regression analysis revealed that the most powerful
independent riskfactors were NHDL/HDL,ApoAl and ApoB100.It is suggested that the levels of
serumApoA1,ApoB100 and NHDL/HDL were the first reference values for evaluating the
develop-ment of CAD.
出处
《湖南医科大学学报》
CSCD
1995年第5期453-456,共4页
Bulletin of Hunan Medical University
关键词
冠状动脉疾病
血脂过多
脂蛋白
coronary disease
coronary
angiography
blood
lipoprotein
hy-perlipidemia
