摘要
为探索人体热暴露过热时血浆脂质过氧化（ＬＰ）和中分子物质（ＭＭＳ）含量的变化及其相互关系，对１８名健康男子，于早餐后进行热暴露２ｈ导致体温升高，当时平均Ｔｒ：３８．６３±０．２４℃，ＨＲ：１２６．６±１７．１ｂｐｍ，ＳＶ：０．８７３±０．３０７ｋｇ，ＰＳＩ：２．２８８，经汗的失水量占体重的１．３１％，尿ＶＭＡ浓度增高２３．１％，２４ｈ尿ＶＭＡ排出量为４７．６±１０．８μｍｏｌ，超过正常范围。但血浆ＭＭＳ浓度几乎无变化，血浆ＭＤＡ浓度增高６．２％，而血浆ＧＳＨ－ｐｘ浓度增高４６．１％（Ｐ＜０．０１），ＧＳＨ－ｐｘ／ＭＤＡ比值增高３５．８％（Ｐ＜０．０５）。实验显示，早餐后的热暴露未能如晚餐后热暴露明显提高血浆ＭＭＳ浓度和防止过热组织过度的ＬＰ。
The aim of this study is to explore progressively the
changes of lipid peroxidation(LP)and medium molecule substance(MMS) concentration in
plasma of hyperthermal human body and their re-lationship.In 18 fit males by exposing to
heat(in sitting position)for 2 h continuously, Hyperthermia was induced. Meanwhile, their mean
rectal temperature was 38.63 ± 0.24℃, mean pulse rate 126.6±17.1 bpm,sweat volume 0.873
±0.307kg, PSI 2.288,and the liquid loss through sweating was e-quivalant to 1.31% of the body
weight.Urine Vanillymandelic acid(VMA)concentration increased by23.1%,24 h urine VMA output
was 47.6±0.8μmol which exceeded the normal limit.But plasma MMS concentration almost no
change, plasma malondialdehyde(MDA) concentration increased by 6.2%,while the
selenium-containing glutathione peroxidase(GSH-px)and GSH-px/MDA ratio in-creased by
46.2%(P<0.01)and 37.3%(P<0.05)respectively. The results showed that heat ex-posure after
breakfast couldn’t increase plasma MMS conentration and prevent the excessive
lipoperox-idation in hyperthermia tissues obviously not like heat exposure after supper.
出处
《航天医学与医学工程》
CAS
CSCD
1995年第2期143-145,共3页
Space Medicine & Medical Engineering
关键词
脂质过氧化
丙二醛
热应激
人体血浆
Lipid peroxidation(LP)selenium-containing glutathione
peroxidase(GSH-px)malondialdehyde(MDA) medium molecule substances(MMS)vanillymandelic
acid (VMA)heatstress humanAddress reprint requests to:Institute of Tropics Medicine,First
Medical College of
