摘要
比较了用灌洗法和用粉碎法处理肺组织提取的两种猪肺泡表面活性物质（ＰＰＳ）对离体灌洗鼠肺顺应性的改善作用。结果：治疗后离体灌洗鼠肺静态肺顺应性恢复程度、压力容量滞后环面积的恢复程度，在对照组为－１．３９％±５．１６％，１．７４％±１８．４８％，在灌洗所得ＰＰＳ（ＬＰＰＳ）组和粉碎法所得ＰＰＳ（ＭＰＰＳ）组分别为９５．８４％±２０．９９％，８８．２±１６．０９％和６４．６７％±１８．２２％，３９．５２％±１６．０９％，均显著高于对照组（Ｐ＜０．０１），ＬＰＰＳ组和ＭＰＰＳ组比较，在前组均大于后组，有显著性差异（Ｐ＜０．０５）．提示：所提取的ＰＰＳ有不同程度的表面恬性，ＬＰＰＳ表面活性优于ＭＰＰＳ。
The effect of porcine pulmonary,surfactants(PPS )obtained with two differentisolating methods on the rat puimonary compliancy were studied. 24 SD rat lungs were divided in-to 3 groups,each group treated with LPPS(PPS obtained with lavaging method),MPPS(PPSobtained with mincing method ) and normal saline(control group ) by tracheal instillation respec-tively. The recovery of pulmonary compliancy and pressure-volume curve ring were determinedand compared before and after treating,with the results of-1.39%±5.16%and 1.74%±18.48% in control group, 95.84%±20. 99% and 88. 2%±16.09% in LPPS group and 64.67%±18.22%and 39.52±16.09%in MPPS group respectively.These results suggested that LPPSand MPPS had surface activity in difference degrees,LPPS being superior than MPPS.
出处
《广东药学院学报》
CAS
1995年第4期244-246,252,共4页
Academic Journal of Guangdong College of Pharmacy
