摘要
合成了一系列新型Ｏ－糖基－甲氧甲酰基膦酰胺酯，并对Ｏ－糖基亚磷酰胺酯与氯甲酸甲酯的Ａｒｂｕｚｏｖ反应及其它有关反应进行了讨论。产物的结构经~１ＨＮＭＲ、^（３１）ＰＮＭＲ、ＩＲ及元素分析确定。初步的生物活性测定结果表明，化合物３_ｅ对人肝癌Ｂｅｌ－７４０２细胞和人白血病ＨＬ－６０细胞有一定的抑制作用。化合物３ａ对烟草花叶病毒有一定的抑制活性．
A series of novel O-saccharidyl-methoxyformylphosphosphonamidates were synthesized,and Arbuzov reaetions of O-saccharidylphosphoramidites with methyl chloroformate and other related reactions were disussed.The structures of the products were determined by￣1H NMR,￣(31)P NMR, IR and elemental analyses. The results of preliminary biological tests showed that compound 3_c possessed some inhibitory activities against Leukaemia HL-60 cells and liver cancer Bel-7402 cells in vitro,compound 3_a has some antivirus activity against tobacco mosaic virus(TMV).
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1995年第12期1899-1902,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学青年基金
天津市21世纪青年基金
关键词
甲酰基膦酰胺酯
抗癌
抗病毒
有机磷
Formylphosphonamidate,Arbuzov reaction,Anticancer activity, Antivirus activity
