摘要
以烷基硫代磷酰二氯为磷酰化试剂，先后分别与４－（喹喔啉－２－氧代）苯酚和相应的取代胺或醇进行磷酰化反应，合成了８个未见文献报道的标题化合物Ⅱａ～ｈ，它们的结构经元素分析，ＩＲ，￣１Ｈ－ＮＭＲ，￣（３１）Ｐ－ＮＭＲ和ＭＳ所证实，并初步研究了它们的波谱性质。
Synthesis of eight new title compounds Ⅱa～h is described.Ⅱa～g were synthesizedby the nucleophilic displacement of alkyl phosphoredichloridothionate by sedium 4-(quinoxalyl-2-oxy)phenolate followed by secondary amines in polar organic solvent under mild conditions,Ⅱh was syn-thesized by the base-catalyzed phosphorylation of 4-(quinoxalyl-2-oxy)phenol using diethyl phospho-rochloridothionate as phosphorylating agent in nonprotonic solvent.The strucrure of all new com-pounds was confirmed by elemental analysis,IR, ￣1H and ￣(31)P-NMR.
出处
《合成化学》
CAS
CSCD
1994年第3期251-257,共7页
Chinese Journal of Synthetic Chemistry
关键词
有机磷化合物
生物活性
硫磷酰胺酯
Organophosphorus compound,4-(quinoxalyl-2-oxy)phenyl phosphoramidothioate,Phosphorylation synthesis.
