摘要
本文对人外周血淋巴细胞染色体最常见的脆性部位3P14进行了扫描电镜的初步观察。发现电镜下fra(3P14)的单体断裂或裂隙可能为DNA纤维的包装不全图象,并表现出不同形态特征。
A preliminary scanning electron microscopical observation on the most common human chromosomal fragile site 3pl4 of the peripheral lymphocytes was reported.It was shown that chromatid break or gap at 3p14 observed under SEM may be a sign of under-packing of DNA filaments and the possibility of various packing-patterns might be in existance.The result of the present work might be of significance in the understanding of natures of breaking or gap of chromatid and may be of help to the study of the mechanisms of chromosomal fragile site formation.
关键词
染色体
脆性部位
扫描电镜
Fragile site,SEM,Chromatid break,Gap,Underpacking
