摘要
已报道自山蒟及石南藤中分得海风藤酮(Ⅰ),denudatin B(Ⅱ),N-isobutyl-deca-trans-2-trans-4-dienamide(Ⅲ),本文继续报道自山蒟中分得一新木脂素,命名为山蒟素D(Ⅳ),X-衍射晶体结构测定为外消旋光学异构体。自石南藤分得Ⅳ的同系物,为新结构、命名为南藤素(Ⅴ),以及山蒟素C(Ⅵ),galgravin(Ⅶ),二氢毕拨明宁碱(Ⅷ)及巴豆环氧素(Ⅸ)。以上化合物皆首次自山蒟及石南藤中分得。以血小板活化因子(PAF)引起的血小板凝集实验测定活性,除Ⅲ,Ⅳ,Ⅶ,Ⅸ外皆有抑制活性。
Platelet activating factor (PAF) is a highly potent endogenous phospholipid mediator, involved in various inflammatory and cardiovascular disorders. As part of a research program dealing with PAF inhibitors isolated from Piper plant species,we have isolated kadsurenone(Ⅰ),denudatin B( Ⅱ ), and N-isobut yl-deca-trans- 2-trans-4 -dienamide( Ⅲ ) from Piped wallichii (Miq.) Hand-Mazz. and P. hancei Maxim. In a continuing search for potential PAF inhibitor from plants, using PAF induced platelet aggregation as a guide, a new neolignan named hancinone D (Ⅳ) was isolated from P. hancei maxim. By X-ray analysis it was identified as a racemate.The X-ray analysis led to a revision of the previously made structure assignment of hancinone C. Another new neolignan named wallichinine (Ⅴ), which was identified as an analogue of(Ⅳ), along with the known compounds hancinone C (Ⅵ), galgravin(Ⅶ), di hydropi perlonguminine(Ⅷ )and crotepoxide (IX) were isolated from P.wallichii (Miq.) Hand-Mazz.The structure determination was based upon spectroscopic analysis. All of the compounds were for the first time obtained from both plants.In the test of platelet aggregation caused by PAF, Ⅰ ,Ⅱ, Ⅴ,Ⅵ, Ⅶ showed inhibitory activity, whereas Ⅲ, Ⅳ, Ⅶ, Ⅸ showed no activity.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第6期438-443,共6页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
关键词
石南藤
魔芋
活性成分
结构
Piper wallichii (Miq.) Hand-Mazz.
P. hancei Maxim.
Hancinone D
Wallichinine
Platelet activating factor
