摘要
本文设计合成了丁公藤碱Ⅱ的C_2脱氧和C_8电子等排类似物。药理结果表明,丁公藤碱Ⅱ的C_2羟基是保持其缩瞳活性的关键部分之一;目的物2和4各自分别具有拟和抗胆碱活性;电子等排目的物16和17既无拟也无抗胆碱作用。
The C_2 deoxy and C_6 electron isosterie analogs of a new antiglaucoma agent, erycibe alkaloid Ⅱ, were designed and synthesized. The main pharmacological results were as follows: 1. The C_2-OH in erycibe alkaloid Ⅱ was one of the key groups for its myotic activity; 2. It was worth noting that compounds 2 and 4 showed cholinergie and anticholinergic activities, respectively. This phenomenon in tropane alkaloids was not reported before; 3. The C_6 electron isosteric compounds 16 and 17 showed neither anticholinergic nor cholinergic activities.
出处
《药学学报》
CAS
CSCD
北大核心
1989年第5期335-340,共6页
Acta Pharmaceutica Sinica
基金
高校科学基金
关键词
丁公藤碱II
拟胆碱能活性
生物碱
Erycibe alkaloid Ⅱ analogs
Cholinergic and anticholinergic activities
