摘要
本文用McAb-ABC法和直接免疫荧光法观察了42例斑秃患者头皮中的郎格罕氏细胞、T细胞亚群及直接免疫荧光改变。斑秃各期表皮中的OKT6^+细胞和Ia细胞无明显差别。多数病人毛球中可见LC,其中活动期最多见。斑秃毛囊中的LC变化主要是T6^+Ia的LC增多,Tb^+Ia的LC增多不显著。毛囊周围的浸润细胞主要是T(OKT_3^-)细胞。活动期T_4细胞及T4/T8比值均高于静止期及恢复期。DIF检查见患者中88％有C_3、IgG及IgM沉积。本文结果提示,斑秃可能是由细胞免疫和体液免疫共同参与的免疫性疾病。
Studies of the scalps from 42 patients with alopecia areala are given,using direct immunofluorescence ( DIP).Langerhans cells (LC)and T-lyrn hocytc subsets are observed.There is no significant difference between the number of OKT6 cells and Ia+ cells in the epidermis of all groups and the control.LC is seen in hair-bulb in many patients and most frequently in active stage.The main change of LC in hair follicle is increasing of T6+Ia- cells,not significant of T6+Ia+ cells.Most of the infiltrates around the hair follicles are T( OKT3+) cells.T4+cells number and T4/T8 ratio in active arc larger than in resting and recovering stages.DIF shows 88% of the patients having deposits of C3,IgG,and IgM.This suggests that alopecia areata may be the disorder of immnue associated with cellular and humoral immunity.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1989年第1期18-21,共4页
Journal of Third Military Medical University
关键词
斑秃
免疫病理
荧光抗体技术
Alopecia arcala/IM
Langerhans cells/UL
T-lymphocytes
Fluorescent antibody technic
