摘要
利用从主胰管注射自身胆汁1ml/kg体重复制的狗急性出血坏死性胰腺炎模型,观察预防应用磷脂酶A_2抑制剂氯喹对肺水肿的影响。实验结果表明胰腺炎组肺系数和肺湿/干重比显著增高,肺血液量和肺血管外水量显著增多,同时支气管肺泡灌洗液中的总蛋白浓度和细胞计数也显著增高。细胞分类可见胰腺炎组巨噬细胞比例显著下降,多形核白细胞和肺泡Ⅱ型上皮细胞比例显著增加。预防应用氯喹对急性胰腺炎肺水肿有显著改善作用,细胞分类中多形核白细胞比例也下降。提示磷脂酶A_2在急性胰腺炎时肺水肿的发生中起重要作用,氯喹对肺水肿的治疗有临床应用价值。
Actute canine hemorrhagic pancreatitis was induced by injection of autobile 1 ml/ kg into the main pancreatic duct, and the effects of pretrcatment with phospholipase A2 inhibitor-chloroquine on pulmonary edema were observed.The results revealed that in animals with acute pancreatitis, lung index and wet to dry lung weight ratio increased significantly, and pulmonary blood volume and extravascular water volume also increased obviously.There were also increments of protein and cell contents in bronchoalveolar lavage fluid.Cell sorting showed significantly decreased percentage of macrophages, and increased percentage of PMN and type n pneumocytes.Pretreat-ment with chloroquine prevented the development of pulmonary edema and the appreciably increased percentage of PMN.This experiment suggests that in acute canine pancreatitis, phospholipase AI may play an important part in pulmonary edema, and chloroquine has potential clinical value in the treatment.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第5期433-437,共5页
Academic Journal of Second Military Medical University
关键词
胰腺炎
肺水肿
氯喹
狗
预防
acute pancreatitis
phospholipase A2
pulmonary edema
chloroquine
dogs
