摘要
应用听觉电生理、内耳病理、内耳酶组织化学、细胞超微结构等指标,研究卡那霉素对缺铁幼鼠内耳损害的规律。结果表明:与对照组相比,缺铁幼鼠内耳损害率高,损害程度严重。卡那霉素与铁缺乏的共同作用对内耳琥珀酸脱氢酶(SDH)活性抑制效果更显著。提示铁缺乏能提高内耳对氨基甙类抗生素(AmAn)的敏度性。铁缺乏可能是目前儿童药物性耳聋发生率高的原因之一。因此对临床上缺铁性贫血的儿童,应慎用卡那霉素。
In this study, we observed the changes of function and structure of inner ear in iron-deficient growing rats receiving kanamycin intramuscularly using auditory elec-trophysiological, histopathological, enzyme histochemical and scanning electron microscopic techniques.The results showed that in an equal dose of kanamycin, the incidence of hearing loss was much higher and the severity of hearing damage, more scr- ious in iron-deficient rats than those in normal rats.The succino-dehydrogenase activity of inner ear was more obviously inhibited by interaction of kanamycin and iron deficiency than that by one of them.Iron deficiency might increase the sensitivity of inner ear to kanamycin.The results indicate that iron deficiency may be one of the reasons for high incidence of drug deafness in children, and it should be cautious when using such drugs in iron-deficient anemia children.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第5期445-449,共5页
Academic Journal of Second Military Medical University
关键词
卡那霉素
耳素性
铁缺乏
耳聋
kanamycin
ototoxicitv
iron deficiency
hearing loss
inner ear
