摘要
三硝基甲苯(TNT)与猪晶体匀浆孵育后,有超氧离子自由基(O_2)与H_2O_2形成;H_2O_2形成剂量效应关系,提示活性氧可能在TNT诱发白内障过程中起一定作用。TNT能显著降低大鼠晶体谷胱甘肽(GSH)的含量,孵育时间并不影响TNT对GSH的降低作用,说明TNT可能对GSH有直接打击作用。
Superoxide radical(O_2) and hydrogen peroxide(H_2O_2) were detected in the pig lens homogenate incubation system incubated with different TNT concentrations. O_2 and H_2O_2 production significantly increased when TNT eoncentration was 5 mM or more. The H_2O_2 production especially showed dose-effect relationship. The GSH level decreased in rat lens homogenate incubation system by TNT, but was not influenced by incubation time. therefore, TNT could affect GSH directly.
出处
《眼外伤职业眼病杂志》
北大核心
1989年第3期129-131,共3页
Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries
