摘要
本实验用犬制作高速弹颅脑火器伤模型,研究了大剂量地塞米松(5mg/kg,致伤后5min静脉注射在防治高速弹颅脑火器伤继发病理损害中的作用。通过生理指标、血和脑脊液酶学、血脑屏障通透性定量指标对比和距伤道的不同距离的光镜和电镜观察研究,证明应用大剂量地塞米松能在一定程度上保护和恢复血脑屏障的结构和功能;保护脑细胞的结构;减轻呼吸和循环系统的继发病理效应,并可减少脑的脂质过氧化物产生等。
The effect of high dos; dexamethasone(5mg/kg wt, intravenous injection)to prevent and treat the secondary pathological damage of craniocerebral injury was studied in animal models of craniocerebral injury caused by high-velocity missiles in dogs.We observed ths physiological changes, analyzed the value of serum and. cerebrospinal fluid lactate dehydrogenase, estimated the permeability of blood brain barrier (BBB) and studied brain pathology by light and electron microscopy.The results suggest high dose dexamethasone can help to restore ths structure and function of BBB, protect brain cells as well as lessai the secondary pathological damage in tha respiratory and circulatory systems and reduce th production of lipoptrox-ides(LPO).
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第3期209-215,共7页
Academic Journal of Second Military Medical University
关键词
颅脑火器伤
血脑屏障
地塞米松
head injury
gunshot wound
experimental model
dexamethasone pathology of brain
brain blood barrier
