摘要
选择了ＳＯＤ及４种Ｃｕ（Ⅱ）络合物，以Ｃｙｔ．ｃ－ＨＸ－ＸＯ法，测其ＳＯＤ样活性；同时，采用反相蒸发法制备了ＳＯＤ及其模拟物的大单层脂质体，以相同的方法测定其ＳＯＤ样活性。结果表明，所有体系均有某种程度的活性，其中Ｃｕ（Ｈｉｓ）２－脂质体体系活性最高，且药物在脂质体中的活性均比在缓冲体系中有不同程度的提高。
SOD-like activities of
SOD and four Cu(Ⅱ)complexes
{Cu(Hsal)2,Cu(His)2,Cu(Dopa)2,Cu(Rutin)2}inphosphate
buffer(pH=7.4)and in liposomes were determined,using cytochrome-c
method.The results showedthat all of the systems had SOD-like
activity to some extent and the Cu(Ⅱ)complex-liposomes systems had
an ap-parent positive cooperative action in which the Cu
(His)2-liposome system displayed the highest activity. These re-sults
could be explained by micellar catalysis and chemical action.
出处
《北京医科大学学报》
CSCD
1995年第4期319-320,共2页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
超氧化物歧化酶
铜铬合物
脂质体
代谢
Headings Superoxide dismutase/metab
Liposomes
Cu(Ⅱ)complex
