摘要
应用兔抗鼠层粘连蛋白抗体、ＰＡＰ免疫组化方法研究８０例食管鳞癌层粘连蛋白的表达。结果显示：癌旁正常上皮、单纯性增生及不典型增生上皮层粘连蛋白均呈连续线状，原位癌呈线状，但可见局部中断，浸润癌层粘连蛋白表达呈多种形式：分化好的团块型及网状型在癌巢周围呈线状，但呈明显不规则和不连续，分化差的细索型癌则常呈碎片状，在癌浸润前缘有时见不定形阳性物质堆积，分析层粘连蛋白表达癌的分级，血管、神经侵犯及淋巴结转移的关系，结果表明层粘连蛋白阳性率在分化好的癌，无血管、神经侵犯及无淋巴结转移组高于分化差的癌，血管、神经侵犯阳性及淋巴结转移组，二者有显著性差异。这既反映了食管鳞癌的异质性，也反映其侵袭性的差异。
cases of esophageal squamous cell carcinome were
studied usingPAP immunohistochemical method.The results were found as
following:continuous linearylaminin expression in normal,hyperplasia
and dysplasia epithalium,lineary expression butfocal interruption in
carcinome in situ,variety staining patterns in invasive
carcinoma,suchas,irregular discontinous lineary expression in
well-differentiated carcinoma with massivestrands and reticular
growth patterns,positive fraginent in poorly differentiated
carcinomawith fine trabecuiar growth patterns,accumuiation of small
cluster of laminin positiveparticles in the front area of cancerous
nests in some cases. The incidence of lamininexuression is higher in
the groups of well-differentiated carcinoma with nagtive
vaseular,perineural invasion and non-lymphnode matastasis as compared
with that in the groupsof poorly differentiated carcinoma with
positive vascular,perineldral invasion and lymph-node
rnatastasis.This results devoted that laminin expression can reflect
both the hete-rogeneity and different invasiveness of esopliageal
carcinoma
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1995年第1期27-29,共3页
Chinese Journal of Cancer
