摘要
ｗｉｓｔａｒ大鼠于孕期ｄ６－１５ｉｐ槐定２７、９、３ｍｇ／ｋｇ，结果高剂量组孕鼠平均增重减少，与阴性对照组相比，死胎率明显上升，胎鼠生长发育迟缓；中、低剂量组未见明显影响。各剂量组均未见畸形胎鼠。本研究结果表明，槐定２７ｍｇ／ｋｇ（约为临床治疗剂量的２７倍）对ｗｉｓｔａｒ孕鼠具有胚胎毒性，但无致畸作用。
The embryotoxicity and teratogenicity of sophoridine were investigated in wistarrats. Sophoridine was administered at 27,9,3mg/kg ip on day 6-15 of the gestation. Ascompared to the solvent control,high dosage of sophoridine(27mg/kg,about 27 times ofclinical dosage)was toxic to pregnant rats and induced embryotoxicity,as measured by per-centage of dead fetuses and delayed skeletogency,No malformation of survial fetuses was ob- served in every group.These studies indicated that sophoridine is embryotoxic,but not ter- atogenic in Wistar rats.
出处
《癌变·畸变·突变》
CAS
CSCD
1995年第3期152-155,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
