摘要
吡硫醇锌(ZPT)急性毒性实验,小鼠灌胃和腹腔注射LD_(60)分别为260mg/k9和22.5mg/kg。中毒症状一致,呼吸抑制可能致死的主因。ZPT长期毒性实验,大鼠与犬的毒性反应基本相同,服药后出现食欲减退和体退减轻。心肝肾功能均正常。病理学检查大剂量组部分动物发生肝浊肿,空泡变。局部应用有轻度刺激性。结果表明ZPT外用是安全的。
LD50 of zinc pyridinethione ( ZPT ) was found to be 22.5 mg/kg ip and 260 mg/kg po in mice. Respiratory inhibition was the cause of death.The long-term toxicity test of ZPT po was carried on for 30 days in rats and 90 days in dogs. These animals showed anorexia and loss of body weight. But their blood picture, renal function and liver function were normal and the changes of heart rate and respiration were insignificant.Pathological examination revealed no abnormality in important organs, including the liver kidney, heart, lungs, spleen, stomach and brain. These results suggest that it is safe to use ZPT externally as an antifungal drug.
出处
《徐州医学院学报》
CAS
1989年第2期98-102,共5页
Acta Academiae Medicinae Xuzhou
关键词
抗真菌药
吡硫醇锌
毒性实验
zinc pyridinethione
LE50
long term toxicity
functions of kidney and liver
heart rate
respiration
pathological analysis
