摘要
本文用１２种抗体对２５例恶性纤维组织细胞瘤（ＭＦＨ）作免疫组化标记。结果３种ＭＦＨ细胞ＰＣＮＡ，Ｖｉ－ｍｅｎｔｉｎ均阳性。组织细胞样ＭＦＨ细胞和少数纤维母细胞样ＭＦＨ细胞并呈ＣＤ６８（Ｋｐ－１和ＰＧ－Ｍ１）阳性。除３例外，ＭＦＨ细胞对肌源性标记，神经源性标记和上皮性标记均阴性。破骨细胞样巨细胞ＰＣＮＡ阴性，ＣＤ６８阳性。多顿氏巨细胞ＰＣＮＡ阴性，ＣＤ６８、Ｍａｃ３８７、ｌｙｓｏｚｙｍｅ、α－ＡＴ呈不同程度阳性。说明ＭＦＨ是原始间叶细胞起源的肉瘤，可以向组织细胞、纤维母细胞双向分化。ＭＦＨ细胞是有高度增殖活性的肿瘤成分，而破骨细胞样巨细胞、多顿氏巨细胞则为缺乏增殖能力的临终细胞。
Twenty five cases of malignant fibrous histiocytoma (MFH) were studied by immunohistochemical method in which 12 antibodies were used. All MFH cells (fibroblast-like tumor cells, histiocyte - like tumor cells, mononuclear and multinuclear tumorous giant cells) were positive for proliferative cell nuclear antigen (PCNA) and vimentin. The histiocyte -like and a few fibroblast-like MFH cells were also positive for CD68 (KP -1 and PG - M1). Except in 3 cases, all MFH cells were negative for myogenic, neurogenic and epitheliogenic markers. Osteoclast-like giant cells were negative for PCNA, but positive for CD68. Touton's giant cells were negative for PCNA, but some of them were positive for CD68, Mac387, lysozyme, α-AT in various degrees. The above findings show that MFH cells originate from primitive mesenchymal cells, and have the possibility to differentiate into both fibroblasts and histiocytes. All MFH cells are tumorous cells which have high proliferative activity, while osteoclast - like and Touton's giant cells have no such activity.
出处
《诊断病理学杂志》
CSCD
1995年第2期82-84,共3页
Chinese Journal of Diagnostic Pathology
关键词
软组织肉瘤
纤维组织细胞瘤
免疫组化
诊断
Sarcoma of soft tissue
Malignant fibrous histiocytoma
Immunohistochemistry
