摘要
Ⅲ型前胶原肽(PⅢP)是Ⅲ型前胶原的氨基端肽。它极易裂解下来,故在体液中可以测到。当Ⅲ型胶原合成旺盛时,PⅢP释放入血量增加,故认为血清PⅢP含量测定是肝纤维增生的良好指标,但亦有相反的报道。N-乙酰-β-氨基葡萄糖苷酶(NAG)参与结缔组织基质的水解,其在血清中活性与肝纤维化有关。
41 cases of liver biopsy were taken from patients with hepatitis. According to the histologic changes, the I to IV grades of liver fibrosis were divided. It is shown that contents of P-Ⅲ-P increased parallel to the degree of liver fibrosis. Serum NAG activity tends to increase at Ⅰ to Ⅲ grade, but is normal at Ⅳ grade of liver fibrosis. The serum P-Ⅲ-P reflects the synthesis of con- nective tissue, while NAG reflects the degradartion of Connective tissue. J This suggests that the measure of the serum contents of P-Ⅲ-P and NAG activity simutanously may help to estimate the imbalance of connective tissure in liver fibrosis.
出处
《临床肝胆病杂志》
CAS
1989年第2期99-99,共1页
Journal of Clinical Hepatology
