摘要
观察１２４例酒精性肝病（ＡＬＤ）的病理变化，根据脂肪变（Ｆ）、炎症（Ｈ）及纤维化（Ｆｂ）的程度，以优势原则进行分类，Ｆ、Ｈ、Ｆｂ均为一级者定为轻症酒精性肝病，各类中主要病变２、３、４级者分别定为该类的轻、中、重亚型。三项病变同级时，则以炎症为主要决定指标。共将ＡＬＤ分为５类：即轻症酒精性肝病（占３０．６％），酒精性脂肪肝（１０．５％），酒精性肝炎（１６．９％），酒精性肝纤维化（３４．７％）和酒精性肝硬化（７．３％）。后者较欧美及日本为少。各类型及其轻、中、重亚型与肝功变化程度一致。同时利用该分类进行二次肝穿前后对比。结果表明本方案适用明确划分病变程度，动态观察病情，指导临床治疗。
Liver biopsy specimen of 124 alcohol
abusers were examined in order to reassess the histological features
and classification of chronic alcoholic liver disease(ALD).The
pathological features are divided into three categories namely fatty
change(F),hepatic change(H)and flbrosis(Fb),each category was graded
into 1-4 degree according to the severity of pathological changes
The classification was made according to the grading of F,H and Fb.If
the grading scores of F,H and Fb were in grade I,it is called alcohol
minimal lesion,if the grading scores of the 3 categories were not
identical,classification was then based on the highest one,Grading
Ⅱ,Ⅲ and Ⅳwere described as mild,moderate and severe type of the
disease。If the three categories have the same grading,then
hepa-titis was used as its diagnotic term.Thus ALD can be classified
into 5 types :(1)Alcoholic minimal lesion(AML 30.6%),(2)Alcoholic
fatty liver(AFL 10.5%);(3)Alcoholic hepatitis (AH16.9%);(4)Alcoholic
hepatic fibrosis (AF34.7%);(5)Alcoholic liver clrrhosis (AC7.3%).AC
is evidently less of percentage in this paper than those found in
Japan.Alterations of liver function tests were paralleI to the
severity of pathological feature,Second fol-low-up biopsies were
performed in l6 patients,2 casc continuing to drink showed more
marked fibrosiS,progressing from Fb2 to Fb3 and Fb4(early cirrhosis).
Those having received carefuI treatment showed better histology.
出处
《肝脏病杂志》
CSCD
1995年第4期205-207,共3页
