摘要
应用多聚酶链反应技术检测１５例急性淋巴细胞白血病患者缓解期骨髓涂片中Ｉｇ基因重排，其中有５例（３３％）检测出残留白血病细胞。回顾性分析结果表明，Ｉｇ基因重排患者均在最后一次完全缓解期（ＣＲ）后２～３个月出现白血病临床复发。ＰＣＲ技术检测微量残留白血病细胞有助于预测白血病复发和指导白血病的化疗。
The rearrangement of immunoglobin genes in the bone marrow slides of 15 cases of acute lymphocytic leukemia in remission stage was studied with PCR.It was found that 5 cases out of the 15(33%)demonstrated residual leukemic cells.Retrospective analysis revealed that clinical relapse would usually occur 2～3months after the last remission in the patients with immunoglobin gene rearrangement,The detection of minute amount of residual leukemic cells with PCR is helpful to predict the relapse of leukemia and to plan a suitable chemotherapy for the relapse.
出处
《第三军医大学学报》
CSCD
北大核心
1995年第3期231-233,共3页
Journal of Third Military Medical University
关键词
白血病
骨髓
基因重排
聚合酶链反应
免疫球蛋白
leukemia
lymphoblastic
PCR
bone marrow examination
immunoglobulin gene rearrangement
