摘要
为探讨缺血对硬变肝脏的损害及激素对温缺血硬变肝脏肝细胞的作用，对２０例合并肝硬化的肝细胞癌病人进行前瞻性临床对照研究。采用Ｐｒｉｎｇｌｅ＇ｓ法行肝切除１４例，其中６例阻断入肝血流前静注地塞米松，肝缺血时间７～１６ｍｉｎ；另６例未阻断血流作对照。通过肝功能、肝组织ＡＴＰ含量和肝细胞超微结构观察，证明Ｐｒｉｎｇｌｅ＇ｓ法入肝血流阻断在硬变肝脏行肝切除时是利多弊少的，但并非所有切肝病例都需要。每次阻断肝血流在１６ｍｉｎ内一般是安全的。地塞米松对温缺血硬变肝脏肝细胞具有保护作用。
A prospective controlled clinical trial has been performed on 20 patients with hepatocellular carcinoma complicated with liver cirrhosis to assess the ischemic injury of the residual cirrhotic liver and the protective effects of steroids on it.Total hepatic inflow was blocked with the Pringle's maneuver in 14 cases prior to the occlusion of the portal triad and dexamethasone was given for the other 6 cases.The duration of hepatic ischemia persisted from 7 to 16 min.Liver function and ATP level of hepatic tissue were determined and ultrastructural changes of hepatocytes were observed.It was confirmed that the Pringle's maneuver can be used in hepatoctomy of cirrhotic liver and temporary arrest of hepatic blood inflow within 16 minutes might be safe for the residual liver through it is not necessary for all the cases;and dexamethasone is able to protect the residual cirrhotic liver from the warm ischemic injury.
出处
《第三军医大学学报》
CSCD
北大核心
1995年第3期227-230,共4页
Journal of Third Military Medical University
关键词
肝肿瘤
外科手术
肝硬变
Pringle's
地塞米松
liver neoplasms/SU
liver cirrhosis
hepatocellular carcinoma
the Pringle's maneuver
dexamethasone
