摘要
应用电镜观察保尔佳对人肝癌、结肠癌细胞超微结构的影响。结果证实，用药组癌细胞未出现明显的超微结构的破坏、而表现为细胞较为分散，形态较规则，细胞表现微绒毛减少，胞质固缩，胞浆内次级溶酶体增多，空泡增多，糖原聚积成斑块状，变性、坏死细胞增多，并出现细胞凋亡现象。提示保尔佳可能是通过抑制癌细胞糖酵解，影响细胞能量代谢，致癌细胞生长受到抑制。
This experiment is an observation of Polyergar's action on the ultrastructure of liver cancer and colon cancer cell under electron-microscopy.The result showed that the cancer cells in the treatment group didn't show obvious ultrastructure damage except that the cells were more dispersed,the villi on the cell surface decreased,cytoplasm shrinked, vacuole increased in number,glycogen aggregated to form a dot-like shape, degenerated and necrotic cell increased, and presence of cellular degeneration appeared.This suggests that Polyergar can inhibit the growth of cancer cell probably through inhibiting the glycolysis of the cancer cell which in turn influenced the cell energy metabolism.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1995年第3期157-160,共4页
Chinese Journal of Clinical Oncology
