摘要
16例ASAⅠ～Ⅱ级，年龄20～60岁，择期颅脑外科手术病人，随机分成两组：Ⅰ组，对照组，Ⅱ组，可乐定组．每组8例．Ⅱ组病人术前口服可乐定5μg／kg。两组病人MAP均较前降低约40％．结果，硝普钠总用县区组比Ⅰ组减少41％（P＜0．01）；Ⅱ组各个时期HR明显低于Ⅰ组（P＜0．05或P＜0．01）；围术期尿量Ⅱ组明显多于Ⅰ组（P＜0．01）。提示，术前口服可乐定可加强硝普纳控制性降压效果，减少其用量，克服其缺点。
16 patients(male 14,female 2, aged 20~60 years, ASA Ⅰ ~ Ⅱ )scheduled for elec-tive cerebral surgery were randomly divided into two groups:Group Ⅰ was control group (n= 8)；Group Ⅱ was clonidine group (n = 8), premedicated with colndine 5pg. Kg-1 peros. MAP of bothgroups was reduced about 4O%. The resultS showed that the totaI dose of ndium nitroprusside re-quired to produce hypotension in group Ⅱ was 41 % lower (P<0.01) lthe heart rate at each stage ingroup Ⅱ was apparently lower than that in group Ⅰ (P<0.01) land the urinary output during oPera-tion in group Ⅱ was apparently higher (P<0. 01). It suggests that clonidine premedication can enfocethe hypotensive action of sedium notroprusside,decrease its dose requirement and overcome its disad-vantage.
出处
《泸州医学院学报》
1995年第4期279-282,共4页
Journal of Luzhou Medical College
关键词
降压药
可乐定
硝普钠
药物相互作用
Antihypertensive agents
Sodium notroprusside
Clonidine
Premedication
