摘要
给小鼠吸人肺炎链球菌同时在尾静脉注射肿瘤坏死因子单克隆抗体，动态检测感染后２１小时内血浆、气管肺泡灌洗液肿瘤坏死因子含量和肺病理的变化，发现肿瘤坏死因子单克隆抗体显著抑制血浆、气管肺泡灌洗液肿瘤坏死因子的升高，抑制白细胞聚集、附壁，减轻白细胞对肺组织的浸润，阻止肺实变的发生。肺炎链球菌及其产物可诱发肿瘤坏死因子释放，肿瘤坏死因子可能是肺炎链球菌感染组织损伤的主要介质。
treptococcus pnumoniae stimulate mouse peri-toneal macrophages to release
tumor necrosis factor al-pha (TNFa) in vitro. When penicillin was added tolysate bacterium,
TNFa release was accelarated. 150Kunming mice were infected with streptococcus pnumo-niae
through inspiration. Dynamic changes of TNFaconcentration in serum and bronchoalveolar
lavage fluidwere detected; pulmonary pathological changes were al-so observed. It was found
that TNFa monoclonal anti-body significantly attennuates TNFa activity in serumand
bronchoalveolar lavage fluid, white blood cellchemotaxis, emigation, and infiltration were
inhibrted.We conclude that streptococcus pnumoniae infectionstimulates TNFa release, and
TNFa is probabaly themajor mediator that causes tissue damage during strep-tococcus
pnumoniae infection. As penicillin accelaratesTNFa release, singal therapy of penicillin may
worsetissue damage.
出处
《中华医学杂志》
CAS
CSCD
北大核心
1995年第1期19-21,共3页
National Medical Journal of China
关键词
肺炎链球菌
肿瘤坏死因子
单克隆抗体
Streptococcus pnumoniae Tumornecrosis factor Monoclonal
antibody
