摘要
对基因重组干扰素γ（ＩＦＮ－γ）体外对３２例骨髓增生异常综合征（ＭＤＳ）患者造血祖细胞的作用进行了研究，结果如下：①ＭＤＳ患者ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ明显低于对照组，ＣＦＵ－Ｅ减低者占３０／３２例，ＣＦＵ－ＧＭ减低者占３１／３２例。②ＩＦＮ－γ体外可促进ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ数增加，其作用为剂量依赖型，在ＩＦＮ－γ浓度为１００Ｕ／ｍｌ时达最大值。③ＩＦＮ－γ对ＭＤＳ患者ＣＦＵ－Ｅ和ＣＦＵ－ＧＭ的促增殖作用与患者自身集落数有关，在自身集落数正常和稍减低者这种作用最明显，在明显减低者这种作用小甚至为０．④上海和日本二种干扰素作用相似，无显著差异。以上结果提示ＩＦＮ－γ对ＭＤＳ治疗可望产生良好效果。
n vitro effects of IFN-γ on the hematopoietic pro-genitor cells from 32 patients with MDS were studied.The results were as follows. ① CFU-E and CFU-GM ofMDS patients were significantly lower than those of con-trols,CFU-E and CFU-GM were decreased in 30 and 31of the 32 patients respectively. ② The numbers of CFU-E and CFU-GM were increased in a dose dependentfashion and reached the maximum at the concentrationof 100U/ml. ③ The proliferative effects of IFN-γ onCFU-E and CFU-GM were correlated with the originalnumbers of CFUs in those patients. The effects weremore pronounced if the CFU numbers were initially nor-mal or only slightly decreased, and less or nil if the origi-nal numbers were significantly decreased. ④The prolifer-ative effects of IFN-γ produced in Shanghai were compa-rable to that prbeuced in Japan. Our results suggest thatIFN-γ may be beneficial to MDS.
出处
《中华血液学杂志》
CSCD
北大核心
1995年第2期62-64,共3页
Chinese Journal of Hematology
关键词
基因重组
干扰素Γ
骨髓增生异常
综合征
Recombinant interferon-γMyelodysplastic syndromesCFU-E CFU-GM
