摘要
对手术方法复制的兔子宫内膜异位症模型，按每千克体重分别应用三烯高诺酮０．０６ｍｇ、０．１２ｍｇ及０．２４ｍｇ（高诺酮组）进行治疗，并与应用丹那唑（每千克体重２０ｍｇ）（丹那唑组）及空白对照组进行比较。结果：高诺酮组异位子宫内膜重量较对照组明显减轻；内膜明显萎缩；血清卵泡刺激素、黄体生成激素和雌二醇水平下降，孕酮无明显变化。高诺酮组中每千克体重应用０．１２ｍｇ者的抑制效应，与丹那唑组相似。提示：三烯高诺酮能明显地抑制异位子宫内膜的生长，可用于治疗子宫内膜异位症。
bjective To study the therapeutic effects of gestrinone on experimental endometriosis in rabbits.Methods Mature female rabbits were laparotomized under sterile condition and three or four seg-ments of endometrium (7mm ×7mm) were sutured to the mesentery of uterus, Seven weeks after oper-ation these animals were divided into 5 groups: control; treated with danazol 20mg/kg; gestrinone0.06,0.12,0.24mg/kg for 4 weeks respectively. At the end treatrnent they were laparotomized again. The ectopic endometrial implants were weighted and their morphologic features were analysed quantita-tively by semi-autornatic image analysis system, meanwhile serum follicular stimulating hormone(FSH), luteinizing hormore (LH) , estradiol (E_2) and progesterone (P) concentrations were determinedby radioimmnoassay.Results Decreased weight and atrophy of ectopic endometrial lmplants were shown in all experi-mental groups, except for control and 0.06mg/kg gestrinone treated-group. In 0.12,0.24mg/kggestrinone treated-group, except for P serum FSH, LH and E_2, concentrations decreased significantly. The degree of inhibition on ectopic lesions of 0.12mg gestrinone group was similar to that of danazolgroup. conclusions Gestrinone inhibits the growth of ectopic endometrial implants in a dose-dependent manner and showed a significant therapeutic effects on experimental endometriosis in rabbits.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第12期735-737,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
诺孕烯酮
子宫内膜异位
疾病模型
Norgestrienone Endometriosis Disease models,animal
