摘要
目的：探讨血ＣＡ１２５测定对子宫肌腺病的诊断价值。方法：采用放射免疫方法对５５例子宫肌腺病（其中１６例术后１周复测）、２０例子宫肌瘤和２０例正常妇女血ＣＡ１２５水平进行测定。结果：３者ＣＡ１２５均值Ｍ（Ｑｌ～Ｑｕ）分别为１０２．１（５６．３～１８２．１）ｋＵ／Ｌ、３４．６（３３．７～４３．８）ｋＵ／Ｌ和３３．１（３２．７～３３．８）ｋＵ／Ｌ，３者间相互比较，差异均有极显著性（Ｐ均＜０．０１）。若以ＣＡ１２５＞５０ｋＵ／Ｌ为阳性，其阳性率３者分别为８０．０％、１０．０％和５．０％，肌腺病者ＣＡ１２５阳性率显著高于其他两者（Ｐ均＜０．００１）。肌腺病患者ＣＡ１２５水平，和子宫大小呈正相关（ｒ＝０．３３，Ｐ＜０．０５）；和未服药者相比，服用性激素药物者ＣＡ１２５水平较低（Ｐ＜０．０５）；手术前、后相比，术后１周的ＣＡ１２５水平明显下降（Ｐ＜０．０１）。结论：ＣＡ１２５测定对子宫肌腺病有明显的辅助诊断价值。
Objective:ToinvestigatethevalueofserumCA125assaysinthediagnosisofuterineadenomyosis.Methods:Fifty-fiveconsecutivepatientswithuterineadenomyosisandtwentywithleiomyomaofuterus,diagnosedbysurgeryandpathologywerestudied.Thebloodsamplesweretak-enonedaybeforeoperation.Twentynormalhealthywomenwereservedascontrols.CA125levelsweredeterminedbyradioimmunoassaymethod.Results:Themedian(M)CA125levels(Ql～Qu)forpatientswithadenomyosis,leiomyomaandnormalcontrolswere102.1(56.3～182.1)kU/L,34.6(33.7～43.8)kU/Land33.1(32.7～33.8)kU/Lrespectively.Thediferencesamongthethreegroupswerealsignificant(P<0.01).TheCA125positiverates(CA125>50kU/L)fortheabovethreegroupswere80.0%,10.0%and5.0%respectively.PatientswithadenomyosishadahigherCA125positiveratethanthosewithleiomyomaornormalcontrols(P<0.001).Forpatientswithade-nomyosistheCA125levelswerepositivelycorelatedwithuterinesize(r=0.33,P<0.05).Theade-nomyosispatientstrea-tingwithsexhormonepreparationswerefoundtohavelowerCA125levelsincomparisonwithnon-users(P<0.05).ThemeanCA125levelmeasuredinsixteenpatientsdecreasedsignificantlyoneweekpostoperation.Conclusions:SerumCA125assayisofgreatassistancetothedi-agnosisofuterineadenomyosisaswelastothediferentialdiagnosisbetweenadenomyosisandleiomyomaofuterus.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1996年第10期590-593,共4页
Chinese Journal of Obstetrics and Gynecology
