摘要
目的:研究微血管密度(MVD)和血管内皮生长因子(VEGF)在肺癌组织中的表达及其与临床病理学参数之间的关系,探讨其在肺癌发生、发展以及血管生成中的作用。方法:采用链霉素抗生物素蛋白过氧化物(SP)免疫组织化学法检测82例肺癌石蜡包埋组织中VEGF和CD34的表达情况。结果:①肺癌组织中MVD值与淋巴结转移、临床分期有关(P<0.05);②VEGF主要表达于肿瘤细胞胞浆或胞膜,与肺癌淋巴结转移、临床分期有关(P<0.05);③肺癌VEGF表达与MVD值有关(P<0.05)。结论:VEGF促进肿瘤血管生成,VEGF表达上调对肺癌发生、发展及转移起重要作用,可作为判定肿瘤的生物学行为和转移潜能的指标。
Objective To evaluate the correlations of expressions of vascular endothelial growth factor (VEGF) in lung cancer tissues and microvascular density (MVD) with various clinicopathological parameters in lung cancer. Methods Streptaridin peroxidase (SP) immunohistochemistry was used to detected the expressions of VEGF and MVD in 82 lung cancer tissues, all the patients did not be treated with antitumor therapy before operation. Results ①The expressions of MVD in lung cancer tissues had correlations with the lymph node metastasis and the clinical stage (P<0.05). ②VEGF mainly expressed in the cytoplasm and cell membrane,had correlations with lymph node metastasis and the clinical stage (P<0.05). ③There was a correlation between MVD and expression of VEGF in lung cancer (P<0.05). Conclusion VEGF can improve the neovascularization, VEGF expression has the positive correlation with the occurrence of lung cancer,VEGF and MVD have became the important criteria to judge the tumor′s biological behaviors.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2005年第4期595-597,F003,共4页
Journal of Jilin University：Medicine Edition
基金
中国加拿大大学项目资助课题(sulcp
#001)
关键词
肺肿瘤
内皮生长因子
内皮
血管
微血管密度
血管生成
免疫组织化学
lung neoplasms
endothelial growth factor
endothelium ,vascular
micovascular density
angiogenesis
immunohistochemistry
