摘要
以３，４，５－三甲氧基甲苯（２）和１０－羟基癸酸（７）为起始原料合成艾地苯醌（１））总收率为４０％。关键步骤弗－克反应和弗瑞麦氏盐氧化反应均在原文献的基础上作了相应的改进。
Idebenone (1) was synthesised from 3,4,5-trimethoxytoluene (2) and 10-hydroxycapric acid (7) in 40% overall yield. The key steps,Friedel-Crafts reaction and Fremy's salt oxidation, were improved on the basis of original literature.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第12期523-531,共9页
Chinese Journal of Pharmaceuticals
关键词
三甲氧基甲苯
艾地苯醌
合成
制药
trimethoxytoluene, 10-hydroxycapric acid, Friedel-Crafts reaction, Fremy's salt oxidation, idebenone, synthesis
