摘要
用一阶导数分光光度法测定甲硝唑口腔粘膜粘附片的溶出速率，定量取导数振幅Ｄ＝｜Ａ＇３００－Ａ＇２９８｜＋｜Ａ＇３４０－Ａ＇３３８｜，结果表明，在１～２０μｇ／ｍｌ范围内Ｄ与浓度呈线性关系（ｒ＝０．９９９８），平均回收率为９９．８％．与直接紫外法相比较，本法的测定结果准确、稳定、可靠，可消除辅料的干扰．
Derivative UV spectrophotometry was used in the determination of dissolution of oral mucosal adhesive tablets of metronidazole.Derivative amplitude D=|A'298-A'300|+|A'338-A'340|was linear witli the concentratfon C over the range 1～20 μ/ml with the correlation coefficient 0.9998.The average recovery was 99.8%.This method is accurate,steady and reliable.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第2期72-75,共4页
Chinese Journal of Pharmaceuticals
关键词
甲硝唑
口腔粘膜粘附片
导数分光光度法
metronidazole,oral mucosal adhesive tablet,in vitro dissolution,derivative UV spectrophotometry
