摘要
目的探讨出生顺序与肝癌发生的关系,估计环境因素与遗传因素在肝癌发生中的相对作用.方法应用Haldane-Smith法和Greenwood-Yule法对肝癌患者进行出生顺序分析.结果用Haldane-Smith法分析97例肝癌患者的出生顺序,∑6A=1 542,∑Χ6A=1 617,C值为0.935(P＞0.20);对肝癌先证者按HBsAg携带状态进行分层分析,HBsAg阳性者的C值为0.950(P＞0.20),阴性者的C值为0.274(P＞0.50).用Greenwood-Yule法比较肝癌患者出生顺序的实际分布和期望分布,显示两者无明显差异,实际数与期望数的比值波动在0.78～1.38,没有随出生顺序而增加或降低的趋势;按肝癌先证者HBsAg携带状态进行分层分析,无论HBsAg阳性或阴性,其出生顺序的实际分布和期望分布均无明显差异,实际数与期望数的比值亦均无随出生顺序而增加或降低的趋势.结论洛阳市肝癌的发生可能与出生顺序无关.
Purpose To explore the relationship between birth order and primary liver cancer(PLC),and to estimate the relative importance of environmental and genetic factors in development of PLC. Methods Birth order analyses for PLC patients were carried out with Haldane-Smith method and Greenwood-Yule method. Results With Haldane-Smith method,birth order analysis for 97 PLC patients showed that,∑6A=1 542,∑χ 6A=1 617,C value was 0.935(P>0.20).Stratified the data by HBsAg status,the C values of PLC patients with HBsAg-positive and HBsAg-negative were 0.950(P>0.20) and 0.274(P> 0.50),respectively.Results of Greenwood-Yule method showed that there was no significant difference between observed distribution and expected distribution of the birth orders for 97 PLC patients,with the ratios of observed number and expected number fluctuating from 0.78 to 1.38,without showing a linear trend of the increasing or decreasing ratios along with the increasing or decreasing birth order.The same results were showed when the data were stratified by HBsAg status. Conclusions The development of PLC was not associated with birth order in Luoyang.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2005年第4期447-450,共4页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金资助项目(39870654)
