摘要
目的 研究不同价态锰染毒后对大鼠脑、肝和心肌内脂质过氧化(MDA)和超氧化物歧化酶(SOD)活力的影响。方法 大鼠经腹腔分别注射氯化锰(MnCl2 ·4H2 O ,Mn2 + )和醋酸锰(C6 H9O6 Mn·2H2 O ,Mn3+ ) ,按6mg kg剂量连续染毒1个月后,测定脑、肝和心肌组织中MDA含量和SOD活力。结果 (1)经Mn2 + 染毒后大鼠脑组织MDA含量与对照组相比,差异有显著性(P <0 0 5 ) ,而Mn3+ 染毒后只有18月龄大鼠脑组织MDA含量显著高于对照组(P <0 0 5 ) ;在肝组织MDA含量,Mn2 + 组与对照组相比,差异有显著性(P <0 0 5 )。(2 )经Mn2 + 、Mn3+ 染毒后18月龄和4月龄大鼠脑组织SOD活力显著低于对照组(P <0 0 5 ) ;经Mn2 + 染毒后,18月龄和4月龄大鼠肝SOD活力明显低于对照组(P <0 0 5 ) ;经Mn3+染毒后,18月龄大鼠肝SOD活力显著低于对照组(P <0 0 5 )。(3 )心肌组织MDA含量,SOD活力与对照组相比,差异均无显著性。结论 不同价态、不同剂量锰染毒不同月龄大鼠对其不同组织MDA含量和SOD活力的影响是不同的。
Objective The effects of different valence manganese on malondialdehyde(MDA) and superoxide dismutase(SOD) in brain, liver and heart of rats were studied.Method four-month and eighteen-month wister rats were chosen to expose to 6 mg/kg Mn (Ⅱ) (MnCl_2·4H_2O) and Mn (Ⅲ) (C_6H_9O_6 Mn·2H_2O) by intraperitoneal injection for successive 30 days, respectively.The content of MDA and the activity of SOD were measured.Results 1.The content of MDA in brain and liver of rats by Mn 2+ was significantly higher than the control group (P<0.05);the content of MDA in brain of eighteen-month old by Mn 3+ was significantly higher than the control group (P<0.05). 2.The activities of SOD in brain of two ages of rats by Mn 2+ and Mn 3+ was significantly lower than the control group (P<0.05);the activities of SOD in liver of two ages of rats by Mn 2+ was significantly lower than the control group (P<0.05); the activity of SOD in liver of eighteen-month old by Mn 3+ was significantly lower than the control group (P<0.05). 3.In heart, no difference was found.Conclusion There are different contents of MDA and activities of SOD in different tissues of four-month old and eighteen-month old rats, which were given different dosage and valence manganese.
出处
《毒理学杂志》
CAS
CSCD
北大核心
2005年第2期108-110,共3页
Journal of Toxicology
基金
国家自然科学基金 (30 0 0 0 1 4 0 )
教育部科学技术研究重点项目 (0 0 1 32 )
北京市科技新星计划 (95581 0 2 80 0 )
