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核苷类抗乙型肝炎病毒药物耐药的分子机制与体外评价 被引量：3

Evaluation of HBV drug-resistance in vitro and the molecular mechanism of resistance to nucleoside analogue therapy
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摘要 核苷类药物是目前抗乙型肝炎病毒(HBV)的主要药物,但它可引起HBV基因的变异,从而引起耐药。作者就核苷类药物引起变异的特点、产生抗药性的分子机制及体外评价等方面作一综述。 Nucleoside analogues are currently the main drug therapy against HBV infection. However, this type of therapy can cause gene mutations in HBV that result in drug resistance. The types of mutations caused by nucleoside analogues and the molecular mechanism of in vitro drug-resistance were reveiwed.
作者 张岩 白雪帆
机构地区 第四军医大学唐都医院解放军感染病诊疗中心
出处 《医学研究生学报》 CAS 2005年第7期647-649,共3页 Journal of Medical Postgraduates
关键词 乙型肝炎病毒 核苷类药物 耐药分子机制 Hepatitis B virus Nucleoside analogues Molecular mechanism of drug-resistance
分类号 R512 [医药卫生—内科学]
  • 相关文献

参考文献15

  • 1Liaw YF. Impact of YMDD mutations during lamivudine therapy in patients with chronic hepatitis B[J]. Antivir Chem Chemother, 2001,12 (Suppl 1):67-71.
  • 2Stuyver LJ, Locarnini SA, Lok A et al. Nomenclature for antiviral-resistent human hepatitis B virus mutations in the polymerase region[J]. Hepatology, 2001,33(3):751-757.
  • 3Ogata N, Fujii K, Takigawa S et al. Novel patterns of amino acid mutations in the hepatitis B virus polymerase in association with resistance to lamivudine therapy in japanese patients with chronic hepatitis B[J]. J Med Virol, 1999,59(3):270-276.
  • 4Paik YH, Chung HY, Ryu WS et al. Emergence of YMDD motif mutant of hepatitis B virus during short-term lamivudine therapy in South Korea[J]. J Hepatol, 2001,35(1):92-98.
  • 5Ben-Ari Z, Mor E, Shapira Z et al. Long-term experience with lamivudine therapy for hepatitis B virus infection after liver transplantation[J]. Liver Transpl, 2001,7(2):113-117.
  • 6Seigneres B ,Pichoud C,Ahmed SS et al. Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B[J]. J Infect Dis,2000,181(4):1221-1233.
  • 7Ono SK,Kato N,Shiratori Y et al.The polymerase L528M mutation cooperates with nucleotide binding-site mutations,increasing hepatitis B virus replication and drug resistance[J].J Clin Invest, 2001,107(4):449-455.
  • 8Das K,Xiong X,Yang H et al.Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine(3TC) and emtricitanbine(FTC)[J]. J Virol, 2001,75(10):4771-4779.
  • 9Lau DT,Khokhar MF,Doo E et al.Long-term therapy of chronic hepatitis B with lamivudine[J]. Hepatology, 2000,32(4 pt 1):828-834.
  • 10Jia-Zhang Xu Zhi-Guo Yang Mei-Zhao Le Mao-Rong Wang Chang-Lun He Yun-Hua Sui Institute of Hepatology,the 81st Hospital of PLA,Nanjing 210002,Jiangsu Province,ChinaDepartment of Pathology,the 81st Hospital of PLA,Nanjing 210002,Jiangsu Province,China.A study on pathogenicity of hepatitis G virus[J].World Journal of Gastroenterology,2001,7(4):547-550. 被引量：8

二级参考文献8

  • 1Linnen J,Wages J,Zhang-Keck ZY,Fry KE,Krawczynski KZ,Alter H,Koonin E,Gallagher M,Alter M,Hadziyannis S,Karayiannis P,Fung K,Nakatsuji Y,Shih JWK,Young L,Piatak JRM,Hoover C,Fernandez J,Chen S,Zou JC,Morris T,Hyams KC,Ismay S,Lifson JD,Hess G,Foung SKH,Th.Molecular cloning and disease association of hepatitis G virus:a transfusion-transmissble agent[].Science.1996
  • 2Xu JJ,Zhou YS,Xu JZ,Ju JL,Wang XX,Chen W,Wang HT.Clonning and sequencing of partial gene of hepatitis G virus (HGV) from Nanjing of China[].Zhonghua Shiyan He Linchuang Bingduxue Zazhi.1997
  • 3He CL,Xu JZ,Wang XY.Clinical and pathological study on chronic non-A,non-B,non-C hepatitis[].Abstracts of the World Chinese Liver Disease Conference.1994
  • 4Simions JN,Leary TP,Dawson GJ,Pilot-Matias TJ,Muerhoff AS,Schlauder GG,Desai SM,Mushahwar IK.Isolation of novel virus-like sequences associated with human hepatitis[].Nature Medicine.1995
  • 5Xu Jiazhang,Wang Haitao,Yang Zhiguo et al. Institute of Liver Diseases,the 81st Hospital of PLA,Nanjing 210002.Clinincal and pathological features of hepatitis G[].CHINESE JOURNAL OF INFECTIOUS DISEASES.1998
  • 6XU jiazhang,JU Jiulong,YANG Zhiguo,et al. Institute of Liver Disease,81 st Hospital of PLA,Nanjing 210002.Dynamic observation of serological and histological changes of Chinese Rhesus monkeys infected by hepatitis G virus[].The Chinese Journal.1999
  • 7许家璋,王海涛,杨志国,乐美兆,隋云华,何长伦.庚型肝炎临床和病理特征[J].中华传染病杂志,1998,16(4):222-225. 被引量：14
  • 8许家璋,鞠九龙,杨志国,乐美兆,汪茂荣.庚型肝炎病毒感染中国恒河猴血清学和肝组织学的动态观察[J].中华实验和临床病毒学杂志,1999,13(1):71-73. 被引量：8

共引文献7

同被引文献37

引证文献3

二级引证文献4

医学研究生学报
2005年 第7期

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