摘要
目的:探讨热休克蛋白90β在鼻咽癌中的表达,评估其在鼻咽癌预后中的作用。方法:用免疫组织化学方法检测50例鼻咽癌组织和鼻咽部炎性组织中热休克蛋白90β的表达情况,分析其与临床病理特征的关系及对预后的影响。结果:HSP90β在鼻咽部炎性组织、鼻咽癌组织中的阳性表达率分别为24·0%、56·0%,在鼻咽癌中的表达阳性率明显高于鼻咽部炎性组织(P<0·01)。鼻咽癌中的HSP90β阳性表达与肿瘤的分化程度有关,随着鼻咽癌分化程度的降低,HSP90β的阳性表达率升高。HSP90β阴性表达者的预后显著优于HSP90β阳性表达者(P<0·05)。结论:HSP90β在鼻咽癌中的表达明显增强,HSP90β过度表达可能与鼻咽癌的发生、发展以及预后有关,HSP90β有可能成为判断鼻咽癌预后的指标之一。
Objective:To investigate the expression of heat shock protein 90β(HSP90β) in human nasopharyngeal carcinoma and the relationship between its expression and prognosis.Methods:Using the immunohistochemical SP method,HSP90β expression was detected in nasopharyngeal tissue from 50 normal individuals,50 patients with nasopharyngeal carcinoma (NPC) and its clinical significance was studied.Results:The positive expression rate of HSP90β was 24.0%,56.0% in normal nasopharyngeal tissue,nasopharyngeal carcinoma tissues respectively. A significantly higher distribution of HSP90β positive expression in NPC tissues compared with normal nasopharyngeal tissue was obtained (P<0.01). The positive expression of HSP90β in NPC was correlated with tumor differentiation. Analysis of patients, survival demonstrated that the prognosis of NPC with HSP90β (-) expression was significantly better than the others.Conclusion:HSP90β is overexpressed in human nasopharyngeal carcinoma. HSP90β was probably concerned with happening, development and prognosis of nasopharyngeal carcinoma. HSP90β could be used as an indicator to judge the prognosis of NPC.
出处
《现代预防医学》
CAS
北大核心
2005年第7期714-716,共3页
Modern Preventive Medicine
基金
国家自然科学基金资助项目(30270524)
关键词
鼻咽癌
HSP90β
免疫组化
Nasopharyngeal carcinoma
Heat shock protein 90β
Immunohistochemistry.
